Dr. Noyal Mariya Joseph

Dr. Noyal Mariya Joseph
Additional Professor
Select List of Former: 
Former Faculty
Medical Registration number: 
76108 (Tamil Nadu Medical Council, 2009)
Academic Qualifications: 

MBBS, MD (Microbiology)

Special Area of Interest: 
TB diagnostics,Biomarkers of TB,Immunopathogenesis of TB meningitis,Drug resistance in <em>Mycobacterium tuberculosis,</em>Non-tuberculous mycobacteria and Detection of Mycobacterium leprae
  1. Perumal P, Abdullatif MB, Garlant HN, Honeyborne I, Lipman M, McHugh TD, Southern J, Breen R, Santis G, Ellappan K, Kumar SV, Belgode H, Abubakar I, Sinha S, Vasan SS, Joseph N, Kempsell KE. Validation of Differentially Expressed Immune Biomarkers in Latent and Active Tuberculosis by Real-Time PCR. https:// doi.org/ 10.3389/fimmu.2020.612564.
  2. Anand E, Biswal N, Joseph NM. Effect of Neutralization of Gastric Aspirate on culture yield of mycobacterium tuberculosis in children with pulmonary tuberculosis. Indian Journal of Tuberculosis, 2020. https://doi.org/10.1016/j.ijtb.2020.12.009.
  3. Thangavelu K, Jamir I, Ellappan K, Krishnakumariamma K, Gopichand P, Das S, Joseph NM. Comparison of MGIT 960 with Lowenstein Jensen Media for Recovery of Mycobacteria from Extrapulmonary Specimens in Southern India. Journal of Clinical and Diagnostic Research 2021;15(3):DC01-DC04.
  4. Johnson WE, Odom A, Cintron C, Muthaiah M, Knudsen S, Joseph N, et al. Comparing tuberculosis gene signatures in malnourished individuals using the TBSignatureProfiler. BMC Infect Dis. 2021;21:106.
  5. Jayakar DS, Joseph NM, Anitha P, Kanungo R. The detection of altered penicillin‑binding protein 2b, autolysin, and pneumolysin genes in Streptococcus pneumoniae colonizing the upper respiratory tract of healthy school children in Puducherry. J Curr Res Sci Med 2019;5:100-4.
  6. Thangavelu K, Krishnakumariamma K, Pallam G, Dharm Prakash D, Chandrashekar L, Kalaiarasan E, Das S, Muthuraj M, Joseph NM. Prevalence and speciation of non-tuberculous mycobacteria among pulmonary and extrapulmonary tuberculosis suspects in South India. J Infect Public Health. 2021;14:320-3.
  7. Kar SS, Sarkar S, Murali S, Dhodapkar R, Joseph NM, Aggarwal R. Prevalence and Time Trend of SARS-CoV-2 Infection in Puducherry, India, August-October 2020. Emerg Infect Dis. 2021;27:666-9.
  8. Krishnakumariamma K, Ellappan K, Muthuraj M, Tamilarasu K, Kumar SV, Joseph NM. Molecular diagnosis, genetic diversity and drug sensitivity patterns of Mycobacterium tuberculosis strains isolated from tuberculous meningitis patients at a tertiary care hospital in South India. PLoS One. 2020;15:e0240257.
  9. Chaudhari KV, Toi PC, Joseph NM. Evaluation of real time polymerase chain reaction targeting mpb64 gene for diagnosis of extrapulmonary tuberculosis. Indian J Tuberc. 2020 https://doi.org/10.1016/j.ijtb.2020.09.009.
  10. Ellappan K, Datta S, Muthuraj M, Lakshminarayanan S, Pleskunas JA, Horsburgh CR Jr, Salgame P, Hochberg N, Sarkar S, Ellner JJ, Roy G, Jose M, Vinod Kumar S, Joseph NM. Evaluation of factors influencing Mycobacterium tuberculosis complex recovery and contamination rates in MGIT960. Indian J Tuberc. 2020;67(4):466-471.
  11. Krishnakumariamma K, Ellappan K, Muthuraj M, Tamilarasu K, Kumar SV, Joseph NM. Molecular diagnosis, genetic diversity and drug sensitivity patterns of Mycobacterium tuberculosis strains isolated from tuberculous meningitis patients at a tertiary care hospital in South India. PLoS One. 2020;15(10):e0240257.
  12. Kalaiarasan E, Thangavelu K, Krishnapriya K, Muthuraj M, Jose M, Joseph NM. Diagnostic performance of real time PCR and MALDI-TOF in the detection of nontuberculous mycobacteria from clinical isolates. Tuberculosis (Edinb). 2020 Sep 1;125:101988.
  13. Anantabotla VM, Antony HA, Joseph NM, Parija SC, Rajkumari N, Kini JR, Manipura R, Nag VL, Gadepalli RS, Chayani N, Patro S. Genetic diversity of Indian Plasmodium vivax isolates based on the analysis of PvMSP3β polymorphic marker. Trop Parasitol. 2019;9(2):108-114.
  14. Hoyt KJ, Sarkar S, White L, Joseph NM, Salgame P, Lakshminarayanan S, Muthaiah M, Vinod Kumar S, Ellner JJ, Roy G, Horsburgh CR Jr, Hochberg NS. Effect of malnutrition on radiographic findings and mycobacterial burden in pulmonary tuberculosis. PLoS One. 2019;14(3):e0214011.
  15. Reddy A, Joseph NM, Khan SP, Bhat S. A mycological study of clinically normal nails and waistbands and their role as sources of infection in patients with tinea corporis. International Journal of Research in Dermatology 2019;5:239-42.
  16. Vijayageetha M, Kumar AM, Ramakrishnan J, Sarkar S, Papa D, Mehta K, Joseph NM, Rajaram M, Rajaa S, Chinnakali P. Tuberculosis screening among pregnant women attending a tertiary care hospital in Puducherry, South India: is it worth the effort? Glob Health Action. 2019;12:1564488. doi: 10.1080/16549716.2018.1564488.
  17. Maruthai K, Kalaiarasan E, Joseph NM, Parija SC, Mahadevan S. Assessment of global DNA methylation in children with tuberculosis disease. Int J Mycobacteriol. 2018;7:338-342.
  18. Leong S, Zhao Y, Joseph NM, Hochberg NS, Sarkar S, Pleskunas J, Hom D, Lakshminarayanan S, Horsburgh CR Jr, Roy G, Ellner JJ, Johnson WE, Salgame P. Existing Blood Transcriptional Classifiers Accurately Discriminate Active TB from Latent Infection in a South Indian Cohort. Tuberculosis (Edinb). 2018;109:41-51.
  19. Dangeti GV, Mailankody S, Neeradi C, Mandal J, Soundravally R, Joseph NM, Kamalanathan S, Swaminathan RP, Kadhiravan T. Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome. Int J Tuberc Lung Dis 2017;22(1):93–99
  20. Hochberg NS, Sarkar S, Horsburgh CR Jr, Knudsen S, Pleskunas J, Sahu S, Kubiak RW, Govindarajan S, Salgame P, Lakshminarayanan S, Sivaprakasam A, White LF, Joseph NM, Ellner JJ, Roy G. Comorbidities in pulmonary tuberculosis cases in Puducherry and Tamil Nadu, India: Opportunities for intervention. PLoS One. 2017;12(8):e0183195.
  21. Neeradi C, Muthu R, Dangeti GV, Soundravally R, Joseph NM, Swaminathan RP, Kadhiravan T. Cerebrospinal Fluid Leukotriene B4 and Soluble Tumor Necrosis Factor Receptor II Levels and Treatment Outcome in Tuberculous Meningitis. J Infect Dis. 2017;216(3):392-394.
  22. Mailankody S, Dangeti GV, Soundravally R, Joseph NM, Mandal J, Dutta TK, Kadhiravan T. Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis. PLoS One. 2017;12(7):e0181262.
  23. Subramaniyan A, Nair S, Joseph NM, Kanungo R. Profile of Multidrug Resistant Acinetobacter Baumannii Infections among Hospitalized Patients. Journal of Medical Science and Clinical Research 2017;5(6):23111-5.
  24. Segar L, Easow JM, Srirangaraj S, Hanifah M, Joseph NM, Seetha KS. Prevalence of Clostridium difficile infection among the patients attending a tertiary care teaching hospital. Indian J Pathol Microbiol. 2017;60(2):221-5.
  25. Shashikala N, Joseph NM, Karnam AHF, Rasitha D, Kanungo R. Failure of educational interventions to reduce use of carbapenems in the intensive care unit of a tertiary care hospital. J Hosp Infect 2016;94:130-131.
  26. Srinivasan G, Muthusamy S, Raveendran V, Joseph NM, Easow JM. Unforeseeable presentation of Chryseobacterium indologenes infection in a paediatric patient. BMC Res Notes. 2016;9(1):212.
  27. Sharma S, Tanigasalam V, Parameswaran N, Chandrasekaran V, Gulati R, Joseph NM, Chandrashekar L. Fulminant BCG Disease in a 7 Month Old Healthy Male Infant. J Trop Pediatr. 2015;61(6):474-7.
  28. Joseph NM, Bhanupriya B, Shewade DG, Harish BN. Relationship between antimicrobial consumption and the incidence of antimicrobial resistance in Escherichia coli and Klebsiella pneumoniae isolates. J Clin Diagn Res. 2015;9:DC08-12.
  29. Khan MS, Kundra P, Cherian A, Joseph NM, Sistla S. Epidemiology of nosocomial infections in an intensive care unit at a tertiary care hospital in southern India: a retrospective study. Int J Infect Control 2015;11(2):7.
  30. Pravin Charles MV, Kali A, Joseph NM. Performance of chromogenic media for Candida in rapid presumptive identification of Candida species from clinical materials. Pharmacognosy Res. 2015;7(Suppl 1):S69-73.
  31. Charles MV, Easow JM, Joseph NM, Ravishankar M, Kumar S, Umadevi S. Role of Appropriate Therapy in Combating Mortality among the Ventilated Patients. J Clin Diagn Res. 2014;8:DC01-3.
  32. Charles MVP, Kali A, Easow JM, Joseph NM, Ravishankar M, Srinivasan S, Kumar S, Umadevi S. Ventilator-associated pneumonia. AMJ 2014;7:334–44.
  33. Joseph NM, Elan S, Vadivu S, Kanungo R. Needlestick injuries among healthcare workers of a tertiary care hospital in South India. Infect Control Hosp Epidemiol. 2014;35:103-5.
  34. Ramu GT, Pramodhini S, Joseph NM, Umadevi S, Srirangaraj S, Stephen S. Virulence Factors of Candida Species Isolated from Respiratory Tract and Urine. Research Journal of Pharmaceutical, Biological and Chemical Sciences 2014;5:955-60.
  35. Joseph NM, Mathias S. Challenges in detection of AmpC β-lactamases among Enterobacteriaceae. Indian J Med Res. 2013;137:216–7.
  36. Kumar MA, Joseph NM, Srikanth K, Stephen S. Conjunctival Myiais caused by Oestrus ovis in a medical college student which responded to Ivermectin. Ann Trop Med Public Health 2013;6:315-6.
  37. Kali A, Charles MP, Noyal MJ, Sivaraman U, Kumar S, Easow JM. Prevalence of Candida co-infection in patients with pulmonary tuberculosis. Australas Med J. 2013;6:387-91.
  38. Joseph NM, Devi S, Shashikala P, Kanungo R. Changing Trend in the Antibiotic Resistance Pattern of Pseudomonas Aeruginosa Isolated from Wound Swabs of Out-Patients and in-Patients of a Tertiary Care Hospital. J Clin Diagn Res. 2013;7:2170-2.
  39. Kali A, Stephen S, Sivaraman U, Kumar S, Joseph NM, Srirangaraj S, Easow JM. Bacteriophage types of methicillin-resistant Staphylococcus aureus in a tertiary care hospital. Australas Med J. 2013;6:496-503.
  40. Kali A, Stephen S, Umadevi S, Kumar S, Joseph NM, Srirangaraj S. Changing Trends in Resistance Pattern of Methicillin Resistant Staphylococcus aureus. J Clin Diagn Res. 2013;7:1979-82.
  41. Charles MP, Easow JM, Joseph NM, Ravishankar M, Kumar S, Sivaraman U. Aetiological agents of ventilator-associated pneumonia and its resistance pattern - a threat for treatment. Australas Med J. 2013;6:430-4.
  42. Desai RP, Joseph NM, Ananthakrishnan N, Ambujam S. Subcutaneous zygomycosis caused by Mucor hiemalis in an immunocompetent patient. Australas Med J. 2013;6:374-7.
  43. Charles MP, Easow JM, Joseph NM, Ravishankar M, Kumar S, Umadevi S. Incidence and risk factors of ventilator associated pneumonia in a tertiary care hospital. Australas Med J. 2013;6:178-82.
  44. Easow JM, Krishnan PK, Kumar S, Joseph NM. Cutaneous manifestations of neonatal sepsis. Australas Med J 2013;6:133.
  45. Joseph NM, Sistla S, Dutta TK, Badhe AS, Chandra Parija S. Role of clinical diagnosis of ventilator-associated pneumonia. Am J Infect Control. 2013;41:471
  46. Umadevi S, Kumar S, Stephen S, Joseph NM. Chromobacterium violaceum: A potential nosocomial pathogen. Am J Infect Control. 2013;41:386.
  47. Mariya Joseph N, Sistla S, Kumar Dutta T, Shankar Badhe A, Rasitha D, Chandra Parija S. Outcome of Ventilator-Associated Pneumonia: Impact of Antibiotic Therapy and Other Factors. Australas Med J 2012;5:135-40.
  48. Zakariya BP, Vishnu Bhat B, Harish B N, Arun Babu T, Joseph NM. Risk factors and outcome of Klebsiella pneumoniae sepsis among Newborns. Curr Pediatr Res 2012; 16: 115-118
  49. Sharmila V, Chaturvedula L, Arun Babu T, Joseph NM, Sistla S. Is Maternal Genital tract Group B Streptococcal Colonization a Predictor of Adverse Obstetric Outcome? A Prospective Cohort Study from South India. Indian J Maternal and Child Health. 2012;14:1-7.
  50. Joseph NM, Kumar MA, Stephen S, Kumar S. Keratomycosis caused by Exserohilum rostratum. Indian J Pathol Microbiol. 2012;55:248-9.
  51. Arun Babu T, Joseph NM. Persistent Earache Due to Tonsillolith. Indian Pediatr. 2012;49:144-5.
  52. Zakariya BP, Bhat B V, Harish BN, Arun Babu T, Joseph NM. Risk Factors and Predictors of Mortality in Culture Proven Neonatal Sepsis. Indian J Pediatr. 2012;79:358-61.
  53. Umadevi S, Joseph NM, Kumari K, Easow JM, Kumar S, Stephen S, Srirangaraj S, Raj S. Detection of extended spectrum beta lactamases, ampc beta lactamases and metallobetalactamases in clinical isolates of ceftazidime resistant Pseudomonas aeruginosa. Brazilian Journal of Microbiology 2011;42:1284-8.
  54. Kumar S, Joseph NM, Easow JM, Singh R, Umadevi S, Pramodhini S, Srirangaraj S, Kumari GK. Prevalence and current antibiogram of staphylococci isolated from various clinical specimens in a tertiary care hospital in Pondicherry. The Internet Journal of Microbiology 2012;10:1.
  55. Charles MVP, Joseph NM, Easow JM, Ravishankar M. Invasive pulmonary aspergillosis caused by Aspergillus versicolor in a patient on mechanical ventilation. Australas Med J 2011;4:632-4.
  56. Sharmila V, Joseph NM, Arun babu T, Chaturvedula L, Sistla S. Genital tract group B streptococcal colonization in pregnant women: a South Indian perspective. J Infect Dev Ctries 2011;5:592-5.
  57. Pradeepkumar NS, Joseph NM. Chromoblastomycosis Caused by Cladophialophora carrionii in a Child from India. J Infect Dev Ctries 2011; 5:556-560.
  58. Easow JM, Joseph NM, Tuladhar R, Shivananda PG. Empyema caused by Eikenella corrodens. J Global Infect Dis. 2011;3:313-5.
  59. Easow JM, Joseph NM, Shankar PR, Rajamony AP, Dhungel BA, Shivananda PG. Streptococcus pneumoniae – a perspective from the Western Region of Nepal. Southeast Asian J Trop Med Public Health 2011;42:912-9.
  60. Babu TA, Joseph NM, Sharmila V. Academic dishonesty among undergraduates from private medical schools in India. Are we on the right track? Medical Teacher 2011;33:759-61.
  61. Kumar S, Umadevi S, Easow JM, Joseph NM, Srirangaraj S, Kumari K, Stephen S. Anterior abdominal wall abscess caused by Streptococcus pneumoniae in a patient with self-inflicted stab injury: An unusual presentation. J Infect Dev Ctries 2011;5:307-309.
  62. Kumar S, Umadevi S, Joseph NM, Kali A, Easow JM, Srirangaraj S, Kandhakumari G, Singh R, Charles P, Stephen S. Detection of inducible clindamycin resistance in staphylococcus aureus and coagulase-negative staphylococci - a study from South India. The Internet Journal of Microbiology 2011;9:2.
  63. Umadevi S, KandhaKumari G, Joseph NM, Kumar S, Easow JM, Stephen S, Singh UK. Prevalence and antimicrobial susceptibility pattern of ESBL producing gram negative bacilli. J Clin Diagn Res 2011;5:236-9.
  64. Srirangaraj S, Ghose S, Joseph NM, Easow JM, Kumar S. Puerperal fever caused by Salmonella typhi. J Obstet Gynaecol. 2011;31:267-8.
  65. Kumar S, Joseph NM, Easow JM, Umadevi S. Multifocal keloids associated with Mycobacterium fortuitum following intralesional steroid therapy: A case report. J Lab Physicians 2011;3:127-9.
  66. Joseph NM, Sistla S, Dutta TK, Badhe AS, Rasitha D, Parija SC. Reliability of Kirby-Bauer disc diffusion method for detecting meropenem resistance among nonfermenting gram-negative bacilli. Indian J Pathol Microbiol 2011;54:556-60.
  67. Kumar S, Hanifah M, Umadevi S, Joseph NM. Cryptococcal meningitis resulting in progressive visual and hearing loss in an AIDS patient. Indian Medical Gazette. 2011;CXLV:160-162.
  68. Umadevi S, Kumar S, Joseph NM, Easow JM, Kandhakumari G, Srirangaraj S, Raj S, Stephen S. Microbiological study of diabetic foot infections. Indian Journal of Medical Specialities 2011;2:12-17.
  69. Zakariya BP, Bhat V, Harish BN, Arun Babu T, Joseph NM. Neonatal sepsis in a tertiary care hospital in South India: bacteriological profile and antibiotic sensitivity pattern. Indian J Pediatr 2011;78:413-7.
  70. Joseph NM, Sistla S, Dutta TK, Badhe AS, Rasitha D, Parija SC. Role of semi-quantitative and quantitative cultures of endotracheal aspirates in the diagnosis of ventilator-associated pneumonia. Australas Med J 2010;3:627-632.
  71. Easow JM, Joseph NM, Dhungel BA, Chapagain B, Shivananda PG. Blood stream infections among febrile patients attending a teaching hospital in western region of Nepal. Australas Med J 2010;3:633-637.
  72. Kumar S, Pajanivel R, Joseph NM, Umadevi S, Hanifah M, Singh R. Pulmonary nocardiosis presenting as bilateral pneumonia in an immunocompetent patient – An unusual host response. The Internet Journal of Microbiology 2010;9(1):19.
  73. Joseph NM, Sistla S, Dutta TK, Badhe AS, Parija SC. Ventilator-associated pneumonia: a review. Eur J Intern Med 2010;21:360-8.
  74. Joseph NM, Sistla S, Dutta TK, Badhe AS, Parija SC. Ventilator-associated pneumonia: role of colonizers and value of routine endotracheal aspirate cultures. Int J Infect Dis 2010;14:e723-9.
  75. Joseph NM, Sistla S, Dutta TK, Badhe AS, Rasitha D, Parija SC. Role of intensive care unit environment and health-care workers in transmission of ventilator-associated pneumonia. J Infect Dev Ctries 2010;4:282-91.
  76. Pradeepkumar NS, Joseph NM, Kotastane D, Kanade V. Students’ perspectives of a pathology museum. Natl Med J India 2010;23:377.
  77. Joseph NM, Sistla S, Dutta TK, Badhe AS, Rasitha D, Parija SC. Ventilator-associated pneumonia in a tertiary care hospital in India: role of multi-drug resistant pathogens. J Infect Dev Ctries 2010;4:218-25.
  78. Joseph NM, Harish BN, Sistla S, Thappa DM, Parija SC. Streptomyces bacteremia in a patient with actinomycotic mycetoma. J Infect Dev Ctries 2010;4:249-52.
  79. Joseph NM, Sistla S, Dutta TK, Badhe AS, Parija SC. Ventilator-associated pneumonia in a tertiary care hospital in India: incidence and risk factors. J Infect Dev Ctries 2009;3:771-7.
  80. Noyal MJ, Harish BN, Bhat V, Parija SC. Neonatal melioidosis: a case report from India. Indian J Med Microbiol 2009;27:260-3.
  81. Noyal MJ, Menezes GA, Harish BN, Sujatha S, Parija SC. Simple screening tests for detection of carbapenemases in clinical isolates of nonfermentative Gram-negative bacteria. Indian J Med Res 2009;129:707-12.
Positions Held: 
  • Member of the nodal team for establishment of RT-PCR centers for COVID-19 testing in Pondicherry, Tamil Nadu and Andhra Pradesh (2020-21)
  • Member Secretary of Plagiarism verification committee of JIPMER (2017 – till date)
  • Executive Member of the JIPMER Scientific Society (2018)
  • Member of Operational Research committee of RNTCP State Task Force (Pondicherry) (2017 – till date)
  • Joint Secretary of IAMM Puducherry Chapter (2013 – 2019)
Special Clinics: