Research
The Department of Pharmacology
Research in Progress:
- Pattern of adherence to MDI and the effect of intervention on the adherence in patients with respiratory diseases.
- In vitro cytotoxic effects of cleistanthins B and diphyllin on colorectal cancer.
- Pharmacogenetics of intravenous fentanyl for postoperative analgesia in South Indian population
- Study on availability, storage, dispensing practices and usage of medicine in selected public health facilities of Pondicherry.
- Epigenetic variations in breast cancer and response to neoadjuvant chemotherapy in a South Indian population.
- Evaluation of clinical significance and prognostic value of circulating tumour cells and comparison of patient derived xenograft animal models in gastric cancer patients.
- Effect of cleistanthins A & B on benign prostatic hyperplasia and prostate cancer: Insights into molecular mechanisms.
- Metformin and valproic acid combination in potentiating the anticancer activity of cisplatin non-small cell lung cancer cell lines
- Influence of smartphone application-based intervention on medication adherence in patients with chronic diseases- A randomized controlled trial.
- Association of calcium channel modulator protein1 (ORAI1) 546C>T and histamine H1 receptor (HRH1) – 17 C>T genetic polymorphisms with the efficacy and safety of non-sedating H1 antihistamines in chronic spontaneous urticaria patients of South Indian origin
- Effectiveness of drug information pamphlets in improving patient medication adherence and usage of commonly prescribed medications and antibiotics among patients in a tertiary care hospital.
- 5- Fluorouracil Degradation Rate (5-FUDR) as a predictive biomarker for adverse effects with 5- Fluorouracil / Capecitabine therapy in South Indian cancer patients – a prospective phenotype genotype association study.
- Hepatoprotective effect of 7 – methoxy coumarin in paracetamol and ethanol toxicity induced cell lines.
- Pattern of adverse drug reaction and medication use in neonatal care units in a tertiary care hospital: a longitudinal observational study.
- Antidiabetic and pleiotropic effects of Psidium guajava Linn leaf extract. as an add on treatment in patients with type 2 diabetes mellitus – A randomized double-blind placebo controlled trial
- Characterization of pncA mutation and treatment outcome among tuberculosis patients
- Characterization of cyclosporine trough (C0) and two-hour post dose concentration (C2) monitoring in children with idiopathic nephrotic syndrome
- Clinical characteristics and early outcome of bedaquiline containing regimens for the treatment of MDR
- Clinical characteristics and treatment outcome of Isoniazid mono-resistance tuberculosis patients: A mixed-method study
- ICMR Rational use of medicines “Evaluation of the prescription pattern of drugs in different OPDs of a tertiary care hospital” task force project
- The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin.
- Subclinical hypothyroidism and plasma levels of commonly prescribed antiepileptic drugs – a cross sectional study.
- Pharmacogenetics of sodium valproate – induced weight gain in South Indian patients
- Formulation and evaluation of topical preparation of Lawsonia inermis L. (Lythraceae) for the evaluation of Capecitabine induced hand – foot syndrome in cancer patients
- Are the users of angiotensin converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) at a higher risk of severe COVID-19? – A Case Control study
- Association of Nucleoside Diphosphate linked moiety X Type motif 15 (NUDT15) C415T and Inosine Triphosphate Pyrophosphatase (ITPA) C94A genetic polymorphisms with azathioprine induced adverse effects in south Indian patients.
- Effect of VDR (Vitamin D Receptor) gene polymorphisms on efficacy of zoledronic acid in south Indian women with postmenopausal osteoporosis; A cross sectional study
- Cytogenetic and molecular characterization of teenage and young adult acute lymphoblastic leukaemia with special emphasis on identification of “Philadelphia like” profile
- Influence of EPHX1 c.337T>C and UGT2B7*2 genetic polymorphism on carbamazepine maintenance dose requirement in person with epilepsy from South India
- Estimating Incremental Cost of treating Antimicrobial Resistant infections in India
- Evaluation of Glycemic Index and Insulin Index of a marketed sugar product
- Effect of Vitamin E on oxidative stress in patients with epilepsy – a placebo controlled randomized trial
Grants obtained (Intramural and extramural)
i) Extramural
| S No | Name of PI | Amount | Period of grant | Agency |
|---|---|---|---|---|
| 1 | Dr. Raveendran R Comparison of patient-derived xenograft animal models of gastric cancer patients. | 29,11,600 | 2022-2024 | ICMR Adhoc |
| 1 | Dr M. Jayanthi Estimating Incremental Cost of treating Antimicrobial Resistant infections in India | Rs. 7,33,450 | 2019-2021 | ICMR Multicentric |
| 2 | Dr M. Jayanthi Evaluation of Glycemic Index and Insulin Index of a marketed sugar product | Rs.2,70,000 | 2020-21 | E.I.D. Parry, Chennai |
| 3 | Dr. R. Raveendran JIPMER – ICMR Rational use of medicines “Evaluation of the prescription pattern of drugs in different OPDs of a tertiary care hospital” task force project | Rs.15,00,000 | 2019-20 | ICMR |
| 4 | Dr. R. Raveendran Evaluation of clinical significance and prognostic value of Circulating tumor cells and Comparison of patient-derived xenograft animal models of gastric cancer patients. | 7,50,000 | 2018-2022 | JIPMER |
| 4 | Dr. Girish. C The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin. | Rs.24,62,475 | 2020-23 | ICMR Adhoc |
| 5 | Dr Girish. C(Co-PI) Drug delivery targeting Lymphatic system: a novel nanomedicine-based approach to fight lymphatic filariasis. | Rs.7,50,000 | 2019-22 | ICMR Adhoc |
| 6 | Dr Girish. C(Co-Investigator) Isolation and characterization of Extracellular vesicles (exosomes) from human Umbilical Cord- derived Mesenchymal stem cells and determination of their | Rs.60,18,600 | 2020-23 | DST |
| 7 | Dr Mirunalini R Clinical characteristics and early outcome of bedaquiline containing regimens for the treatment of MDR | Rs 30,000 | 2019-20 | Tuberculosis Association of India |
| 8 | Dr Mirunalini R Clinical outcome and microbiological profile of septic neonates receiving AWaRe group of antibiotics – Descriptive study in a neonatal ICU in South India | Rs 20,000 | 2020 | ICMR STS |
Intramural
| S No | Name of PI | Amount | Period of grant | Agency |
|---|---|---|---|---|
| 1 | Dr M. Jayanthi (PhD thesis) Formulation and evaluation of topical preparation of Lawsonia inermis L. (Lythraceae) for the evaluation of Capecitabine induced hand – foot syndrome in cancer patients | Rs. 7,50,000 | 2020-23 | JIPMER |
| 2 | Dr M. Jayanthi (MD dissertation) 5- Fluorouracil Degradation Rate (5-FUDR) as a predictive biomarker for adverse effects with 5- Fluorouracil / Capecitabine therapy in South Indian cancer patients – a prospective phenotype genotype association study. | Rs. 1,99,450 | 2021-23 | JIPMER |
| 3 | Dr.Kesavan.R (PhD thesis) Pharmacogenetics of intravenous fentanyl for postoperative analgesia in South Indian population | Rs 2,25,000 | 2019-22 | JIPMER |
| 4 | Dr.Kesavan.R (PhD thesis) Pharmacogenetics of sodium valproate-induced weight gain in South Indian patients | Rs 4,00,000 | 2019-21 | JIPMER |
| 5 | Dr.Girish.C The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin. | Rs.1,75,000 | 2020 | JIPMER |
| 6 | Dr Girish C Hepatoprotective effect of 7-methoxycoumarin in paracetamol and ethanol induced liver toxicity models in vitro. | Rs.2,00,000 | 2021 | JIPMER |
| 7 | Dr. Harivenkatesh N (MD dissertation) Influence of smart phone application based intervention on medication adherence in patients with chronic diseases - A Randomized controlled trial | Rs.2,00,000 | 2020 | JIPMER |
| 8 | Dr.Harivenkatesh N (MD dissertation) Pharmacokinetics of colistin in patients with multidrug resistant Gram negative bacterial infections | Rs.2,00,000 | 2020 | JIPMER |
| 9 | Dr.Harivenkatesh N (MD dissertation) Pharmacokinetics of Vancomycin in patients with Methicillin Resistant Staphylococcus Aureus Infections | Rs.1,50,000 | 2020 | JIPMER |
| 10 | Dr R.Priyadharsini(MD dissertation) Association of polymorphisms of Calcium modulator protein1 (ORAI1) 546C>T and Histamine H1 receptor (HRH1) -17C→T genes with the efficacy and safety of non sedating H1antihistamines in chronic spontaneous urticaria patients South Indian origin | Rs.1,91,000 | 2019-20 | JIPMER |
| 11 | Dr R.Priyadharsini (MD dissertation) Association of Nucleoside Diphosphate linked moiety X Type motif 15 (NUDT15) C415T and Inosine Triphosphate Pyrophosphatase (ITPA) C94A genetic polymorphisms with azathioprine induced adverse effects in south Indian patients. | Rs 1,50,000 | 2019-20 | JIPMER |
| 12 | Dr Mirunalini R (MD dissertation) Clinical characteristics and treatment outcome of Isoniazid mono- resistance tuberculosis patients A mixed-method study | Rs 50,000 | 2020-22 | JIPMER |
| 13 | Dr Suganthi S. (MD dissertation) Pattern of adverse drug reaction and medication use in neonatal care units in a tertiary care hospital: a longitudinal observational study. | Rs. 35,000 | 2021-21 | JIPMER |
| 14 | Dr. Anusha. N (Faculty Project) Subclinical hypothyroidism and plasma levels of commonly prescribed antiepileptic drugs – a cross sectional study. | Rs. 1,20,000 | 2021-2022 | JIPMER |
| 15 | Dr. Anusha. N (MD dissertation) Effect of Vitamin E as an add-on therapy on oxidative stress in patients with epilepsy – a randomized placebo controlled trial | Rs. 2,00,000 | 2022-2024 | JIPMER |