Research

The department undertakes various faculty and residents research projects and collaborates with other departments in JIPMER and other institutions. The department is also collaborating with clinical trials. The department focuses on research addressing the epidemiologic, therapeutic and preventive aspects targeting the relevant kidney ailments in the local population.

Focus areas of research

  • CKD of unidentified aetiology – community prevalence, aetiology and preventive measures.
  • Sarcopenia and  Acidosis in CKD
  • Predictive models for AKI to CKD transition
  • Pragmatic trials on chronic Kidney disease and AKI.
  • Living Kidney Donor evaluation and outcomes
  • Dialysis Quality and Safety
  • COVID-19 in patients with End-Stage Renal Disease
  • Registry for glomerular diseases

Ongoing Extramural funded projects

  • Indian Chronic Kidney Diseases study
  • Renal Registry
  • Sree Narayandasji Santram Maharaj Improving Dialysis Outcome Initiative
  • Sponsored Clinical Trial- VIS649-201 enVISion study

Research staff

  • Bavithra S- Research associate
  • Vijayalakshmi M S- Project assistant
  • Ms Janani V –Data entry operator
  • Nithya V- Data entry operator
  • R Hemalakshmi – Clinical trial coordinator
  • Sreelekha Addagada- Pharmacist

Publications

  1. Dubey AK, Sahoo J, Vairappan B, Parameswaran S, PS Priyamvada. Recognizing the importance of physical activity on sarcopenia in chronic kidney disease . Osteoporosis and Sarcopenia .2022;8:32-33
  2. Sejpal KN, C. Xenotransplantation.Indian Journal Of Kidney Diseases.2022;1:13-17
  3. Arora S,Ramachandran N,Srinivas BH,Rajesh NG, Parameswaran S, Priyamvada S.Thrombotic Microangiopathy: An Under-Recognized Cause of CKD Following Viper Envenomation. Kidney International Reports (2022) 7, 1441–1442
  4. Sejpal KN , Priyamvada PS, Parameswaran S, Rajesh N G, Chellappan A. Recurrent Crescentic Infection Related Glomerulonephritis: A rare presentation. Indian Journal Of Kidney Diseases.2022;1:30-37
  5. Priyamvada P S. Endocrinological aspects of glomerular diseases. ClinicalKeyNow. https://www.clinicalkey.com/now/in/content/76-s2.0--in_en_endocrinological aspects of glomerular_diseases
  6. Zachariah VK, Gandhi BS, Sunitha VC, Priyamvada PS, Parameswaran S. Windswept deformity of lower limbs in a patient with end-stage renal disease and rickets. Kidney International .2022 101(1), 190.
  7. Denson J L, Gillet A S, Zu Y, Brown M, Pham T, Yoshida Y et al Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19. JAMA Netw Open. 2021;4(12):e2140568.
  8. Parameswaran S, Kulothungan SA, Ponnusamy M, Reddi S, Haridasan S, Manikandan R, Priyamvada PS, Vazhayil A, Lalgudi DN, Sreenivasan SK, Radhakrishnan J. Low glomerular filtration rate in apparently healthy young individuals is an important factor preventing kidney transplantation from living kidney donors – A single-center observational study from India. Indian J Transplant [serial online] 2021 [cited 2022 Jan 4];15:325-31.
  9. Yadav AK, Ghosh A, Divyaveer S, Mukhopadhyay B, Kundu M, Kumar V et al and the Indian Chronic Kidney Disease Study Group. Serum catalytic iron and progression of chronic kidney disease: findings from the ICKD study, Nephrology Dialysis Transplantation, 2021;, gfab271
  10. Arora S, Priyamvada P S, Sahoo JP, Vairappan B Parameswaran S.Seasonal changes in Kidney function in CKD of uncertain etiology. Kidney International Reports; https://doi.org/10.1016/j.ekir.2021.08.011
  11. Dubey AK , Sahoo J, Vairappan B, Parameswaran S, Priyamvada PS. Prevalence and determinants of sarcopenia in Indian patients with chronic kidney disease stage 3 & 4. Osteoporosis and Sarcopenia.2012 ; 7( 4):153-158
  12. John O, Gummudi B, Jha A, Gopalakrishnan N, Kalra O P, Kaur P et al. Chronic Kidney Disease of Unknown Etiology in India: What Do We Know and Where We Need to Go. Kidney Int Rep. 2021 Aug 9;6(11):2743-2751.
  13. Puthiyottil D, Priyamvada PS, Kumar MN, Chellappan A, Zachariah B, Parameswaran S. Role of Urinary Beta 2 Microglobulin and Kidney Injury Molecule-1 in Predicting Kidney Function at One Year Following Acute Kidney Injury. Int J Nephrol Renovasc Dis. 2021;14:225-234
  14. Prasad N , Yadav AK, Kundu M, Sethi J, Jaryal A, Sircar D,. Modi G K, Kamboj K, Sahay M, Gopalakrishnan N, Kaur P, Vikrant S, Varughese S, Agrawal SB, Singh S, Gang S, Parameswaran S, Kumar V, Ghosh A,Jha V. Prescription Practices in Patients With Mild to Moderate CKD in India. Kidney Int Rep. 2021. https://doi.org/10.1016/j.e kir.2021.06.011 Epub ahead of print
  15. Ariga K, Dutta TK, Haridasan S, Pillai Puthenpurackal PS, Harichandrakumar KT, Parameswaran S. Chronic Kidney Disease after Snake Envenomation Induced Acute Kidney Injury. Saudi J Kidney Dis Transpl 2021:32:146-56. DOI: 10.4103/1319-2442.318516
  16. JIPMER Deceased Donor Transplantation Committee (JDDTC). Establishing a deceased donor transplantation program and its impact in a public sector hospital in India – A single centre experience from India. Indian J Transplant 2020; 14:321-32
  17. Parameswaran S, Rinu PK, Kar SS, Harichandrakumar KT, James TD,Priyamvada PSP, Haridasan S, Mohan S, Radhakrishnan J. A Newly Recognized Endemic Region of CKD of Undetermined Etiology (CKDu) in South India—“Tondaimandalam Nephropathy”. Kidney Int Rep. 2020, 15;5(11): 2066-2073. DOI: 10.1016/j.ekir.2020.08.032.
  18. Avinash Kumar Dubey, Jayaprakash Sahoo, Balasubramanian Vairappan, Satish Haridasan, Sreejith Parameswaran, PS Priyamvada. Correction of metabolic acidosis improves muscle mass and renal function in chronic kidney disease stages 3 and 4: a randomised-controlled trial. Nephrol Dial Transplant.2020;35(1):121-29. DOI: 10.1093/ndt/gfy214.. PMID:30053298.
  19. M Naveen Kumar, PS Priyamvada, Anand Chellappan, KV Sunooj, BH Srinivas, NG Rajesh, Ezhilnilavan Sampath, Sreejith Parameswaran. Membranous nephropathy secondary to indigenous Indian medications containing heavy metals. Kidney International Reports .2020: 5; 1510–14 1016/j.ekir.2020.06.015
  20. M Kumar, P Priyamvada, R Ganga, B Harsha, S Parameswaran. Bilateral perinephric collections in nephrotic syndrome. Indian Journal of Nephrology .2020 30 (5), 346-346
  21. Modi GK, Yadav AK, Ghosh A, Kamboj K, Kaur P, Kumar V, Bhansali S, Prasad N, Sahay M, Parameswaran S, Varughese S, Gang S, Singh S, Sircar D, Gopalakrishnan N, Jaryal A, Vikrant S, Baid-Agrawal S, Jha V. Nonmedical Factors and Health-Related Quality of Life in CKD in India. Clin J Am Soc Nephrol. 2020 7;15(2):191-199. doi: 10.2215/CJN.06510619.
  22. P S Priyamvada, Challa Jaswanth, Bobby Zachariah, Satish Haridasan, Sreejith Parameswaran, Rathinam Palamalai Swaminathan, Prognosis and long-term outcomes of acute kidney injury due to snake envenomation. Clinical Kidney Journal, 2020; 13(4):  564–70, https://doi.org/10.1093/ckj/sfz055
  23. Dubey AK, Priyamvada PS, Sahoo J, Vairappan B, Haridasan S, Parameswaran S. Reliability of Anthropometry-Based Equations Compared to Dual Energy Absorptiometry for Assessing Body Composition in Predialysis Chronic Kidney Disease-A Longitudinal Study. J Ren Nutr. 2020;30(3):216-222.DOI: 10.1053 /j.jrn.2019.08.007.
  24. Sreejith Parameswaran, Suman Lata, Santhosh Satheesh, Manikandan Ramanitharan. Decision-making in complex clinical scenarios using an ethical framework: Kidney transplantation in a patient with severe left ventricular dysfunction. Indian J Transpalnt 2019;13 (3):221-4
  25. Jaswanth C, Priyamvada PS, Zachariah B, Haridasan S, Parameswaran S, Swaminathan RP.Short term changes in urine beta 2 microglobulin following recovery of acute kidney injury resulting from snake envenomation. Kidney Int Rep.2019;  28;4(5):667-673. PMID:31080921
  26. Haridasan S, Ganesh RN, Parameswaran S, Priyamvada PS. Manifest interstitial and vascular pathology in anti-neutrophil cytoplasmic antibody-associated renal disease. Saudi J Kidney Dis Transpl.2019;30(3):726-734. DOI: 10.4103/1319-2442.261359.
  27. Viswanath N, Harichandra Kumar KT, Haridasan S, Parameswaran S, Priyamvada PS.Functional Status in Hemodialysis A Comparative Study with FIM, ADLQ and 7D5LInstruments. Indian J Nephrol.2019;29(3):172-178. PMID: 31142963
  28. Puthiyottil D, Ramesh A , Dhodapkar R, Ramanitharan M, Mishra SK, Pathak N , Choudhury SR , Vazhayil AP ,Lalgudi DN ,Kodakkattil SS,Priyamvada PS. Parameswaran S. Successful kidney transplantation from a deceased donor with chronic hepatitis B infection and review of literature. Indian J Transpalnt. 2019;13 (4) :292-6
  29. Goutham KTC, Harichandrakumar KT, Dhanin P, Priyamvada PS, Haridasan S, Parameswaran S. Persistent Metabolic Acidosis on Regular Hemodialysis or Peritoneal Dialysis. Indian J Nephrol. 2019;29(2):84-89. doi:10.4103/ijn.IJN_309_17
  30. S Ezhilnilavan, S Elango, Satish H, Sreejith Parameswaran, PS Priyamvada. Pseudoaneurysm of thyrocervical trunk following left internal jugular vein cannulation.2018;28(2):173-174. PMID:29861572
  31. Parvanova A, Trillini M, Podestà MA, Iliev IP, Aparicio C, Perna A, Peraro F, Rubis N, Gaspari F, Cannata A, Ferrari S, Bossi AC, Trevisan R, Parameswaran S, Chávez-Iñiguez JS, Masnic F, Seck SM, Jiamjariyaporn T, Cortinovis M, Perico L, Sharma K, Remuzzi G, Ruggenenti P, Warnock DG. Blood Pressure and Metabolic Effects of Acetyl-l-Carnitine in Type 2 Diabetes: DIABASI Randomized Controlled Trial. J Endocr Soc. 2018 :22;2(5):420-436. doi: 10.1210/js.2017-00426.
  32. S Ezhilnilavan, PS Priyamvada, S Haridasan, NG Rajesh, S Parameswaran. Acute gastric dilatation in a patient with lupus nephritis: An uncommon presentation of lupus mesenteric vasculitis. Saudi J Kidney Dis Transpl. 2018;29(2):429-434. PMID:29657215
  33. S Ezhilnilavan, PS Priyamvada, BH Srinivas, H Satish, S Parameswaran. Acute tubulointerstitial nephritis following hymenopteran stings. Postgrad Med J. 2018;94(1113):418-420. PMID:29626057
  34. PS Priyamvada, R Jayasurya, Vijay Shankar, S Parameswaran. Epidemiology and outcomes of acute kidney injury in critically ill: Experience from a tertiary care center. Indian J Nephrol. 2018;28(6):413-420. PMID:30647494
  35. Satish H, Parameswaran S, Srinivas BH, Rajesh NG, Jayasurya R, Padhi R, Priyamvada PS. Early Eosinophilic Antibody-mediated Rejection in a Renal Allograft Recipient. Indian J Nephrol. 2018 ;28(5):389-392. doi: 10.4103/ijn.IJN_102_17
  36. India State-Level Disease Burden Initiative Diabetes Collaborators. The increasing burden of diabetes and variations among the states of India: the Global Burden of Disease Study 1990-2016. Lancet Glob Health. 2018;6(12):e1352-e1362. doi: 10.1016/S2214-109X(18)30387-5.
  37. Parameswaran S, Jha V. Acute Kidney Injury in the Tropics: Epidemiology, Presentation, Etiology, Specific Diseases, and Treatment. Core Concepts in Acute Kidney Injury. 2018;221-235. Published 2018 May 2. doi:10.1007/978-1-4939-8628-6_14
  38. Haridasan S, Parameswaran S, Bheemanathi SH, Chandrasekhar L, Suseela BB, Singh R, Rabindranath J, Padhi RK, Sampath E, Dubey AK, Puthenpurackal PSP. Subcutaneous phaeohyphomycosis in kidney transplant recipients: A series of seven cases. Transpl Infect Dis.2017;19(6). 
  39. India State-Level Disease Burden Initiative Collaborators. Nations within a nation: variations in epidemiological transition across the states of India, 1990-2016 in the Global Burden of Disease Study. Lancet. 2017;390(10111):2437-2460. doi: 10.1016/S0140-6736(17)32804-0.
  40. Manavalan M, Majumdar A, Harichandra Kumar KT, Priyamvada PS. Assessment of health-related quality of life and its determinants in patients with chronic kidney disease. Indian J Nephrol. 2017;27(1):37-43. PMID:28182041
  41. Kumar V, Yadav AK, Gang S, John O, Modi GK, Ojha JP, Pandey R, Parameswaran S, Prasad N, Sahay M, Varughese S, Baid-Agarwal S, Jha V. Indian chronic kidney disease study: Design and methods. Nephrology (Carlton). 2017 ;22(4):273-278. doi: 10.1111/nep.12789. 
  42. P S Priyamvada, Vijay Shankar, Srinivas B H, Rajesh N G, S Parameswaran. Acute interstitial nephritis following snake envenomation: A single centre experience. Wilderness Environ Med. 2016;27(2):302-6. PMID:26970860
  43. Ravindranath J, Pillai PP,  Parameswaran S, Kamalanathan SK, Pal GK Body Fat Analysis in Predialysis Chronic Kidney Disease: Multifrequency Bioimpedance Assay and Anthropometry Compared With Dual-Energy X-Ray Absorptiometry. J RenNutr.2 2016;26(5):315-9.DOI: 10.1053/j.jrn.2016.04.002. PMID:27238245
  44. Morkhandikar S, PS Priyamvada, Srinivas BH, Parameswaran S. Cerebral venous thrombosis in a patient with acute postinfectious glomerulonephritis. Indian J Nephrol. 2016 26(3):209-11 PMID:27194837
  45. SK Rampelli, NG Rajesh, BH Srinivas, KT Harichandra Kumar, RP Swaminathan, PS Priyamvada. Clinical spectrum and outcomes of crescentic glomerulonephritis: A single-centre experience. Indian J Nephrol. 2016;26(4):252-256 ·
  46. Jayasurya R, Srinivas B H, Ponraj M, Haridasan S, Parameswaran S, P S Priyamvada. Karyomegalic interstitial nephropathy following Ifosfamide therapy. Indian J Nephrol.  2016; 26(4):294-297
  47. P S Priyamvada, S. Morkhandikar, B. H. Srinivas1, S. Parameswaran .Heavy and Light chain amyloidosois presenting as complete heart block: A rare presentation of a rare disease. Indian J Nephrol. 2015;25(2):106-9.PMID:25838650
  48. Parameswaran S, Shankar V, Parameswaran N, Swaminathan RP. Severe skeletal deformities in inappropriately treated distal renal tubular acidosis. Kidney Int. 2015;88(5):1200. doi: 10.1038/ki.2015.43.
  49. Jayasurya R, Murugesan N, Kumar R, Dubey AK, Priyamvada PS, Swaminathan RP, Parameswaran S. Spontaneous nontraumatic subarachnoid hemorrhage without cerebrovascular malformations in a maintenance hemodialysis patient. Indian J Nephrol. 2015;25(5):310-4. doi: 10.4103/0971-4065.156909
  50. Parameswaran S, Satheesh S, Morkhandikar S, Shankar V, Jayasurya R, Padhi RK, Priyamvada PS, Swaminathan RP. Successful salvage of thrombosed arterio-venous fistula with thrombolytic therapy using tissue plasminogen activator. Indian J Nephrol. 2015;25(2):110-2. doi: 10.4103/0971-4065.136888
  51. P S Priyamvada, Sreejith Parameswaran, Sandeep Morkhandikar, Vijay Shankar. Successful eradication of cryptosporidium in kidney transplant recipients. Two case reports, Indian Journal of Transplantation 2014,8:22-24.
  52. P S Priyamvada, Ravindranath Jayasurya, Bheemanathi H. Srinivas, Sreejith Parameswaran. Acute interstitial nephritis following viper bite: a rare association C.lin Kidney J,2014; 7 (2): 221-22. PMID:25852878
  53. P S Priyamvada, S. Parameswaran, M. Sandeep, V. Shankar, R. P. Swaminathan. Medullary sponge kidney and isolated hemi hyperplasia. Indian J Nephrol, 2014; 2( 4): 243-45 PMID:
  54. Jha V, Parameswaran Community-acquired acute kidney injury in tropical countries.Nature Reviews Nephrology.2013; 9,:278-90
  55. Parameswaran Swaminathan, RBelatacept: Good, but not good enough .Journal of Pharmacology and Pharmacotherapeutics; 2012 ; 3 (1 ) 82-83. DOI:10.4103/0976-500X.92510

Book chapters

  1. P S Priyamvada, R Jayasurya. Chronic Kidney Disease. Lecture NotesNephrology: A Comprehensive Guide to Renal Medicine. Eds Surjit Tarafdar. John Wiley &Sons,  2020.
  2. Parameswaran S, Pathak N. Chapter 75: Mani MK. Experience with a program for prevention of chronic renal failure in India. Kidney Int. 2005; 67: S75 - S78.Articles A Nephrologist Should Know. First Edition. Dakshinamurty V, Siva Kumar V, Ram R, Sangeeth Lakshmi B (Eds.). 2019 March.
  3. Pathak N, Parameswaran S. Chapter 76: Mani MK. Treating Renal Disease inIndia's Poor: The Art of the Possible. Semin Neph. 2010; 30(1): 74-80. Article A Nephrologist Should Know. First Edition. Dakshinamurty V, Siva Kumar V, Ram R, Sangeeth Lakshmi B (Eds.). 2019 March.
  4. Parameswaran S. Approach to Oliguria and Polyuria. Essentials of Nephrology. Ed. Kasi Visweswaran. 3rd Edition. 2019.
  5. Parameswaran S, Jha V. Acute Kidney Injury in the Tropics: Epidemiology, Presentation, Etiology, Specific Diseases, and Treatment. Core Concepts in Acute Kidney Injury. (pages 221-235), Springer, Ed. SS Waikar, 2018.
  6. Parameswaran S. ‘ Acute Kidney Injury in the book Clinical pathways in Emergency Medicine (Pages 621-636), Ed. Suresh David, Springer, 24 May 2016
  7. Parameswaran S. Hematinic Agents (Chapter 32), in the book ‘ Prescribing Drugs in Renal Disease’ Ed: Kasi Visweswaran, Kothari Publishers, 2014
  8. Parameswaran S, Vimala A. Hematopoiesis Stimulating Agents (Chapter 33), in the book ‘ Prescribing Drugs in Renal Disease’ Ed: Kasi Visweswaran, Kothari Publishers, 2014
  9. Parameswaran S, Chellapan A, RP Swaminathan. Wearable Artificial Kidney (WAK) – A Review. Postgraduate in Nephrology. Ed. K.V. Dakshinamurthy. 2011.
  10. Parameswaran S, Kohli H.S. Peritoneal dialysis in the acute care setting. ECAB clinical update Nephrology – CAPD. Eds. Gupta A, Singhal M.K., Elsevier, 2010
  11. Parameswaran S, Jha V. Primary Glomerular Diseases: Clinicopathologic Correlation. ECAB clinical update Nephrology – Primary Glomerular Diseases. Ed. Ramdas Pisharody., Elsevier, 2010
Last Updated :05-Jul-2022