Research

The Department of Pharmacology

Ongoing Research Projects:

  1. Pattern of adherence to MDI and the effect of intervention on the adherence in patients with respiratory diseases.
  2. Prevalence of adulteration of non-allopathic medicines with allopathic medicines.
  3. Influence of CYP3A5*3 genetic polymorphism on dose adjusted plasma levels of carbamazepine in epileptic patients in South Indian population.
  4. Effect of vitamin D as add-on therapy in vitamin D deficient polycystic ovarian syndrome women: a randomised double blind placebo controlled trial.
  5. In vitro cytotoxic effects of cleistanthins A & B on colorectal cancer and stem cells.
  6. Pharmacogenomics of gemcitabine in patients with metastatic lung cancer
  7. Pharmacogenomics of bleomycin –induced pulmonary toxicity in South Indian cancer patients.
  8. Efficacy and safety of Curcuma longa on cardiac endothelial function in native Tamilians with Type-2 Diabetes mellitus: A randomized double blind, parallel arm, placebo controlled trial.
  9. Effect of  ABCB1 C3435T genetic polymorphism on clinical response of carbamazepine in South Indian epileptic patients.
  10. Protective effect of gallic acid and quercetin on anti-tubercular drug induced liver injury and its possible mechanisms in in vivo and in vitro models.
  11. Medicine use and availability in public health facilities of Pondicherry.
  12. Epigenetic variations in breast cancer and response to neoadjuvant chemotherapy in a South Indian population.
  13. Evaluation of clinical significance and prognostic value of circulating tumor cells and comparison of patient derived xenograft animal models in non-small cell lung cancer patients.
  14. Effect of cleistanthins A&B on benign prostatic hyperplasia and prostate cancer: Insights into molecular mechanisms.
  15. Adverse effects of tacrolimus and its associated risk factors in renal transplant recipient.
  16. Efficacy of epalrestat and benfotiamine in patients with diabetic neuropathy: A randomized controlled trial.
  17. Association between genetic polymorphisms rs628031 (1222 A>G) and rs622342 (1386C>A) in SLC22A1 gene and gastrointestinal adverse effects with metformin treatment in south Indian patients with type 2 diabetes mellitus: A cross-sectional study.
  18. Effect of silymarin as an adjunct to standard treatment in depressive disorder. A biomarker based exploration.
  19. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double blind randomized controlled trial.
  20. Estimation of prevalence of anti-platelet action of aspirin and its candidate gene polymorphism in South Indian population: A cross sectional study.
  21. Role of therapeutic drug monitoring in predicting efficacy & toxicity of intravenous amikacin in hospitalized patients with urinary tract infection:a hospital based prospective study.
  22. Anti-hypertensive and pleiotropic effects of Phyllanthus emblica extract as an add on therapy in patients with newly diagnosed essential hypertension - A randomized double blind, parallel arm, placebo controlled trial.
  23. Serum valproate concentrations and therapeutic outcome in patients with bipolar disorder: an observational study in a tertiary care setting.
  24. CYP2C19 genetic variants and non-genetic factors influencing voriconazole induced adverse effects in South Indian patients with haematological malignancies.
  25. Pharmacokinetics of colistin in patients with multidrug resistant Gram negative bacterial infections.