Research

 Research and Publications

a) Research Completed

  • Carbamazepine induced headache in patients with epilepsy: a case control study.
  • Comparison of efficacy of local corticosteroid injection into carpal tunnel: Distal Vs Proximal approaches in patients with carpal tunnel syndrome
  • Neuroimaging in localization related epilepsy
  • Retrospective analysis of association of changes in Median Nerve size parameters measured by serial ultrasonography with clinical electrophysiology response in patients with CTS
  • Cerebrovascular reactivity and postural alterations in cerebral blood flow velocity in patients with ischemic stroke: a case control study

b) Research in Progress

  • Auditory processing and auditory working memory in children with BECTS (ENT)
  • A study to assess utility of Novel induction –de induction technique in patients with suspected Psychogenic Non-epileptic seizure (PNES.)
  • Comparison of safety and efficacy of amitriptyline and gabapentin in migraine prophylaxis randomized double blinded double dummy trial.
  • Association of CYP2C19* 2(681G >A) allele & UGT1A6*2 (552A>C) allele genetic polymorphism on valproic acid-induced weight gain in persons living with epilepsy (PWE) from South India
  • Comparison of combined extension MRI and 3DT2 W SPACE sequence with standard MRI protocol in cervical spondylosis
  • Vascular cognitive decline in young stroke subjects
  • Autonomic function tests in subjects with epilepsy: a case control study
  • Randomized double blind placebo-controlled trial of Sodium ozagrel and Edaravone in acute ischemic stroke (EDOZ) (CTRI REF/2012/03/003334)
  • Adaptation and validation of a semantically, Trans culturally and operationally equivalent Tamil version of the Dissociative Experiences Scale II (DESII) in patients with Psychogenic Non-Epileptic Seizure patients (PNES)
  • Autonomic dysfunction in People Living with Epilepsy (PWE) on Carbamazepine versus other Antiepileptic Drug Monotherapy: A ComparativeCross sectional study
  • Prevalence of Restless Legs Syndrome in Patients of Chronic Liver Disease
  • Prevalence of Restless Legs Syndrome in Patients of Chronic Kidney Disease
  • Translation and validation of International Restless Leg Syndrome Study Group rating scale and Restless Legs Syndrome Quality of Life Questionnaire in Tamil language.
  • Biochemical derangements related to metabolic Syndrome in Epileptic patients receiving Phenytoin and Sodium valproate
  • Influence of ABCB1 3435C>T genetic polymorphism on clinical response of carbamazepine in South Indian epileptic patients. n collaboration with Department of pharmacology
  • Spectral EEG, MRI Brain, genetic profile (MECP2) in autistic spectrum disorders in Tamilian Children in and around Pondicherry: a descriptive study
  • Pharmacogenomic profile of oral anticoagulants in collaboration with Department of pharmacology
  • Prehospital patient management profile in acute strokes in collaboration with Emergency Medicine department
  • Clinical profile of a cohort of atrial fibrillation patients in collaboration with Department of Medicine and Cardiology.
  • Quality of life in stroke patients: In collaboration with nursing college, JIPMER
  • Tilt table variations in Transcranial Doppler parameters in ischemic stroke patients: A case-control study
  • Adherence to oral anticoagulants in secondary stroke prevention
  • Randomized controlled trial to compare the effect of coupled transcranial stimulation versus decoupled transcranial stimulation and sham stimulation as motor enhancement therapy in chronic ischemic stroke cases.
  • Peripheral Nerve Injury: Suturing or Scaffold? An in vivo study followed by a clinical trial

c) Grants obtained (Intramural and extramural)

 

Extramural

  • CMR grant for Indian stroke Research Network (InSTRUCT and SPRINT)
  • CSIR grant for postdoctoral fellowship in peripheral nerve injury
  • DST-SEB grant for postdoctoral fellowship in “Effect of Vedic chants in Autism” study

Intramural

  • Comparison of safety and efficacy of amitriptyline and gabapentin in migraine prophylaxis randomized double blinded double dummy trial: Dr. Satish/Dr.Vaibhav Wadwekar
  • Autism: Genetic, Spectral EEG and MRI study: Dr. Mohan/Dr. Sunil K Narayan

d) Patents applied for / awarded

Provisional patent was granted for “Combo-Tube” for coma care for a project from Neurology Department by Dr. Bototo Deb, Medical Student under the guidance of Dr. Sunil K Narayan, Senior Professor of Neurology.

e) Publications--Indexed Journals

  1. Nair PP, Menon RN, Radhakrishnan A, Cherian A, Abraham M, Vilanilam G, Kesavadas C, Thomas B, Alexander A, Thomas SV. Is 'burned-out hippocampus' syndrome a distinct electro-clinical variant of MTLE-HS syndrome? Epilepsy Behav.2017 Apr;69:53-58.
  2. Chandrasekharan SC, Menon V, Wadwekar V, Nair PP. High Frequency of Depressive Symptoms among Adults with Epilepsy: Results from a Hospital-based Study. J Neurosci Rural Pract. 2017 Aug;8(Suppl 1):S13-S19
  3. Venkatesh M, Chakkalakkoombil SV, Nair PP, Sowkar UB. Idiopathic bilateral hypertrophic olivary degeneration. BMJ Case Rep. 2017 Dec 22.2017
  4. Chakkalakkoombil SV, Venkatesh M, Nair PP, Sowkar UB. Intradiploic cephalocele: a rare entity at a rare site. BMJ Case Rep. 2018 Jan 10
  5. Menon D, Menon RN, Kesavadas C, Mahadevan A, Radhakrishnan A, Kannoth S, Nair PP, Abraham M, Thomas B, Thomas SV. Clinical-radiological-pathological correlation in an unusual case of refractory epilepsy: a two-year journey of who dunit! Epileptic Disord. 2018 Feb 1;20(1):51-59.
  6. Elavarasi A, Dash D, Bhatia R, Warrier A, Jain D, Kumar L et al. Spinal cord involvement in primary CNS lymphoma. J Clin Neurosci (2017), https://doi.org/10.1016/j.jocn.2017.10.027
  7. Elavarasi A, Dash D,Tripathi M, et al. Cerebellar ataxia and neuropathy as presenting features of hepatitis-B related cirrhosis and portal hypertension. BMJ Case Rep doi:10.1136/bcr-2017-221912
  8. Naik RD, Gupta K, Soneja M, Elavarasi A, Sreenivas V, Sinha S. Sleep quality and quantity in intensive care unit patients: A cross-sectional study. Indian J Crit Care Med 2018;22:408-14
  9. Elavarasi A, Goyal V, Vishnu VY, Singh MB, Padma MV. Pediatric Chronic inflammatory demyelinating polyneuropathy: A case series. Indian J Pediatr (2017). https://doi.org/10.1007/s12098-017-2536-5
  10. Kadeeja N, Senthilnathan N, Viswanathan S, Aghoram R. Sporadic hypothyroidism-related hypokalemic paralysis: Diagnosis in resource-poor setting. J Family Med Prim Care 2017; 6(4):862-64
  11. Sethuraman VK, Balasubramanian K, Viswanathan S, Aghoram R. Inadvertent skipping of steroids in septic shock leads to a diagnosis of adult onset stills disease. Cureus 2017; 9(1):e978
  12. Gokhroo RK, Anantharaj A, Bisht D, Kishor K, Plakkal N, Aghoram R, Mondal N, Pandey SK, Roy R. A pediatric echocardiographic Z-score nomogram for a developing country: Indian pediatric echocardiography study - The Z-score. Ann Pediatr Cardiol 2017;10(1):31-38
  13. Palugulla S, Dkhar SA, Kayal S, Narayan SK. Oxaliplatin-induced Peripheral Neuropathy in South Indian Cancer Patients: A Prospective Study in Digestive Tract Cancer Patients. Indian J Med Paediatr Oncol. 2017; 38(4):502-507.
  14. Palugulla S, Thakkar DN, Kayal S, Narayan SK, Dkhar SA. Association of Voltage-Gated Sodium Channel Genetic Polymorphisms with Oxaliplatin-Induced Chronic Peripheral Neuropathy in South Indian Cancer Patients. Asian Pac J Cancer Prev. 2017;18(11):3157-3165.
  15. Laskar AM, Bhat P, Pottakkat B, Narayan S, Sastry AS, Sneha R. A multimodal intervention to improve hand hygiene compliance in a tertiary care center. pii: S0196-6553(17)31358-5. doi: 10.1016/j.ajic.2017.12.017. [Epub ahead of print]
  16. Palugulla S, Devaraju P, Kayal S, Narayan SK, Mathaiyan J. Genetic polymorphisms in cyclin H gene are associated with oxaliplatin-induced acute peripheral neuropathy in south Indian digestive tract cancer patients. Cancer Chemother Pharmacol. pii: S0196-6553(17)31358-5. doi: 10.1016/j.ajic.2017.12.017. [Epub ahead of print]
  17. Tiruppur C, Ramakrishan R, Somasundaram K, Narayan SK et al. Efficacy and safety of intravenous tenecteplase bolus in acute ischemic stroke: Results of two open label, Multicenter trial. American Journal of cardiovascular drugs.

 Publications -- Non-indexed Journals

None

 Book Chapters/Conference Proceedings

  • Pradeep P Nair- Status epilepticus in special situations; In status epilepticus practical guidelines in management Ed Ashalatha Radhakrishnan (Jaypee):
  • Sivakumar R, Jayaraj M , Pradeep P Nair:Reflex epilepsy syndromes: in Pediatric epilepsy sundrome Ed Ashalatha Radhakrishnan(Jaypee)