Research

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Thrust areas:

  1. Perinatal asphyxia / Therapeutic hypothermia
  2. Neonatal sepsis
  3. Quality Improvement
  4. Human Milk Banking
  5. Neurodevelopmental outcome of high risk neonates
  6. Kangaroo Mother Care

Funded projects

Sl. No Name of Principal Investigator Title of Project Funding Agency Amount Status

1

 Dr. Vishnu Bhat

DNA methylation, inflammatory mediators and placental histology in relation to outcome in intrauterine growth restricted babies

Intramural

 

3,50,000/-

Ongoing

2

Dr. Vishnu Bhat

Therapeutic hypothermia and Neuronal biomarker in term neonates with HIE-RCT

DBT

17,99,504/-

Ongoing

3

Dr. Nishad Plakkal

Goat Lung surfactant for RDS-Multicentric study

AIIMS

30,00,000/-

Completed

4

Dr. Vishnu Bhat

Effectiveness of family centered early intervention on neurobehavioral and developmental outcome of infants with hypoxic ischemic encephalopathy.

Intramural

3,00,000/-

Ongoing

5

Dr. Adhisivam

Does gastric lavage with expressed breast milk reduce the incidence of NEC among VLBW infants?-RCT

Intramural

2,25,000/-

Ongoing

Recently Completed projects

  1. Impact on Human Breast Milk Bank on the mortality and morbidity pattern in NICU of a tertiary care hospital
  2. Does Fluid restriction improve outcome in infants with perinatal asphyxia undergoing systemic hypothermia? A pilot randomized parallel group controlled trial
  3. Neurodevelopmental outcomes of preterm IUGR neonates  - a prospective cohort study

Other ongoing projects

  1. Predictor of mortality and major morbidities among very low birth weight neonates.
  2. Efficiency of oropharyngeal administration of colostrum in reducing morbidity and mortality in very preterm infants- randomised controlled trial.
  3. Quality improvement initiative to reduce postnatal growth failure in very low birth weight babies
  4. Magnesium sulfate as an adjunct to therapeutic hypothermia in term infants with hie, randomised controlled trial
  5. BCG Denmark - Green Signal Lab versus no BCG: effect on neonatal mortality among babies <2000g birth weight (BLOW Trial 2)

Recent Publications

1.Bharadwaj S, Bhat VB, Vickneswaran V, Adhisivam B, Zachariah B, Habeebullah S. Oxidative stress in preeclamptic mother - newborn dyads and its correlation with early neonatal outcome - a case control study. J Matern Fetal Neonatal Med. 2018 ;31(12):1548-1553

2.Gopal N, Koner BC, Bhattacharjee A, Bhat V, Murugaiyan SB, Muddegowda PH. Assay of urinary protein carbonyl content can predict the steroid dependence and resistance in children with idiopathic nephrotic syndrome. Saudi J Kidney Dis Transpl. 2017 Mar-Apr; 28(2):268-272.

3.Kumar P, Adhisivam B, Vishnu Bhat B. Clofibrate as an Adjunct to Phototherapy for Unconjugated Hyperbilirubinemia in Term Neonates. Indian J Pediatr. 2017 May 17.

4.Tanigasalam V, Vishnu Bhat B, Adhisivam B, Plakkal N, Harichandra Kumar KT. Vasambu (Acorus calamus) Administration: A Harmful Infant Rearing Practice in South India. Indian J Pediatr. 2017 May 3.

5.Adhisivam B, Vishnu Bhat B, Poorna R, Thulasingam M, Pournami F, Joy R. Postnatal counseling on exclusive breastfeeding using video - experience from a tertiary care teaching hospital, south India. J Matern Fetal Neonatal Med. 2017 Apr;30(7):834-838.

6.Adhisivam B, Venkatesh C. Media and Measles-Rubella Vaccination Campaign – Musings from Pondicherry. Indian Pediatrics 2017; 54: 421- 422

7.Adhisivam B, Nivedita M, Nishad P, Vishnu Bhat. A lesson from the neonatal unit. BMJ May 15, 2017.

8.Francis F, Bhat V, Balachander B, Khare C, Bethou A, Dalal A, Ponnala R. Look Up to Diagnose Down! Indian J Pediatr. 2017 Jul 29.

9.Vishnu Bhat B, Mondal N. Outcome of Extreme Preterm Babies Treated with Ventriculo-Peritoneal Shunt for Post Hemorrhagic Hydrocephalus. Indian J Pediatr.2017 Jul 26. 10.Gurugubelli Krishna R, Vishnu Bhat B. Molecular mechanisms of intrauterine growth restriction. J Matern Fetal Neonatal Med. 2017 Jul 10:1-7.

11.Rajalakshmi, R, Vetriselvi, P, Nivedita Mondal N. Effect of tactile-kinesthetic stimulation on weight gain and neuromuscular maturity in preterm neonates. International Journal of Current Research.2017 July 9,55062-55066.

12.Gokhroo RK, Anantharaj A, Bisht D, Kishor K, Plakkal N, Mondal N. A pediatric echocardiographic Z-score nomogram for a developing country: Indian pediatric echocardiography study – The Z-score. Annals of Pediatric Cardiology. 2018;11(1):109-111. 13.Durga KD, Adhisivam B, Vidya G, Vishnu Bhat B, Bobby Z, Chand P. Oxidativestress and DNA damage in newborns born to mothers with hyperglycemia - aprospective cohort study. J Matern Fetal Neonatal Med. 2017 Jul 12:1-6.

14.Rakesh K, Vishnu Bhat B, Adhisivam B, Ajith P. Effect of therapeutichypothermia on myocardial dysfunction in term neonates with perinatal asphyxia - a randomized controlled trial. J Matern Fetal Neonatal Med. 2017 Jul 6:1-6.

15.Solanki R, Mondal N, Mahalakshmy T, Bhat V. Medication errors by caregivers athome in neonates discharged from the neonatal intensive care unit. Arch DisChild. 2017 Jul;102(7):655-658.

14.Banupriya N, Vishnu Bhat B, Benet BD, Sridhar MG, Parija SC. Efficacy of zinc supplementation on serum calprotectin, inflammatory cytokines and outcome inneonatal sepsis - a randomized controlled trial. J Matern Fetal Neonatal Med.2017 Jul;30(13):1627-1631.

15.Kingsley SMK, Bhat BV. Role of microRNAs in sepsis. Inflamm Res. 2017Jul;66(7):553-569. 

16.Tanigasalam V, Gowda M, Plakkal N, Adhisivam B, Vishnu Bhat B. Sirenomelia with VACTERL association-a rare anomaly. Pediatr Neonatol. 2017 Sep 27.

17.Banupriya N, Bhat BV, Benet BD, Catherine C, Sridhar MG, Parija SC. Short Term Oral Zinc Supplementation among Babies with Neonatal Sepsis for Reducing Mortality and Improving Outcome - A Double-Blind Randomized Controlled Trial. Indian J Pediatr. 2017 Sep 11.

18.Adhisivam B, Bhat V, Banupriya N, Poorna R, Plakkal N, Palanivel C. Impact of human milk banking on neonatal mortality, necrotizing enterocolitis and exclusive breastfeeding - experience from a tertiary care teaching hospital, south India. J Matern Fetal Neonatal Med. 2017 Oct 18:1-11. 

19.Francis F, Bhat V, Mondal N, Adhisivam B, Jacob S, Dorairajan G, Harish BN. Fetal inflammatory response syndrome (FIRS) and outcome of preterm neonates – a prospective analytical study. J Matern Fetal Neonatal Med. 2017 Oct 11:1-5.

20.Thomas N, Abiramalatha T, Bhat V, Varanattu M, Rao S, Wazir S, Lewis L,Balakrishnan U, Murki S, Mittal J, Dongara A, Prashantha YN, Nimbalkar S. Phase Changing Material for Therapeutic Hypothermia in Neonates with Hypoxic Ischemic Encephalopathy - A Multi-centric Study. Indian Pediatr. 2017 Dec 14. pii:S097475591600103. [Epub ahead of print]

21.Hebbar M, Kanthi A, Shrikiran A, Patil S, Muranjan M, Francis F, Bhat B V, Girisha KM, Shukla A. p.Arg69Trp in RNASEH2C is a founder variant in three Indian families with Aicardi-Goutières syndrome. Am J Med Genet A. 2018 Jan;176(1):156-160. doi: 10.1002/ajmg.a.38522. Epub 2017 Nov 17.

22.Adhisivam B, Kohat D, Tanigasalam V, Bhat V, Plakkal N, Palanivel C. Does fortification of pasteurized donor human milk increase the incidence of necrotizing enterocolitis among preterm neonates? A randomized controlled trial. J Matern Fetal Neonatal Med. 2018 Apr:1-6.

23.Adhisivam B, Vishnu Bhat B, Rao K, Kingsley SM, Plakkal N, Palanivel C. Effect of Holder pasteurization on macronutrients and immunoglobulin profile of pooled donor human milk. J Matern Fetal Neonatal Med. 2018 Mar 27:1-4.

24.Tanigasalam V, Vishnu Bhat B, Adhisivam B, Balachander B, Kumar H. Hypothermia detection in low birth weight neonates using a novel bracelet device. J Matern Fetal Neonatal Med. 2018 Mar 4:1-4.

25.Vishnu Bhat B, Adhisivam B. Human Milk Banking and Challenges in Quality Control. Indian J Pediatr. 2018 Apr;85(4):255-256.

26.Vishnu Bhat B, Plakkal N. Non-pharmacologic Measures for Pain Relief in Preterm Neonates. Indian Pediatr 2018 Apr;55:287-288.

27. Vishnu Bhat B, Adhisivam B. Can We Reduce the Duration of Antibiotic Therapy for Neonatal Pneumonia? Indian J Pediatr. 2018 Jul 28

Vishnu Bhat B.