Research

DEPARTMENT OF DERMATOLOGY AND STD

Research Completed

  1. Midline cutaneous lesions in neonates and spinal dysraphism.
  2. Noninvasive assessment of methotrexate induced hepatotoxicity in psoriasis patients
  3. Dermatological manifestations of systemic hematological malignancies and its treatment
  4. Prevalence and patterns of latex allergy among health workers of a tertiary care centre in south India
  5. Clinical characterization and relevance of patch test, prick test and sensitization to Malassezia species in patients with adult onset atopic dermatitis.
  6. Comparison of MASI scores between low fluence and high fluence Q-switched Nd:YAG laser for refractory melasma: A randomized controlled trial.
  7. Neonatal and infantile skin care practices and cultural perspectives in Puducherry: a mixed method study.
  8. Factors affecting the severity of seborroheic dermatitis.
  9. Surgical matricectomy vs phenolisation after lateral nail plate avulsion in the treatment of ingrown toenails: single blinded randomised control trial

Research in Progress .

  1. Immunologic prediction of relapse in patients with pemphigus vulgaris in clinical remission.
  2. Punch excision & grafting  versus subcision followed by ultra pulse co2 resurfacing in acne atrophic scars - a randomised controlled study.
  3. Effectiveness of bleach bath and routine hygienic measures versus routine hygienic measures alone in preventing recurrence of pyoderma in children aged ≤ 14 years: A randomized controlled open label trial.
  4. Epidermal Growth Factor Receptor (EGFR) expression and disease activity in patients with pemphigus vulgaris.
  5. Therapeutic outcome of DPCP and its correlation with lesional immune cell subtypes and serum cytokine profile in alopecia areata – a pilot study
  6. Methotrexate with standard dose of cetirizine versus updosing of cetirizine in H1 anti-histamine resistant chronic spontaneous urticaria: An open label study
  7. Clinico-pathological study of patients with lichen planus pigmentosus
  8. Anal cytology and human papilloma virus testing for screening of anal intraepithelial neoplasia among men having sex with men attending a designated Sexually Transmitted Infection (STI) clinic in South India
  9. Clinico-epidemiological profile and quality of life in treated Hansen’s patients with chronic neuropathic pain
  10. Factors associated with relapse in patients with alopecia areata
  11. Clinical characterization and patch testing in children with foot eczema
  12. Comparison of Modified Melasma Area and Severity Index (mMASI) scores between low fluence Q-switched Nd:YAG laser versus 35% glycolic acid peels for melasma: A randomised controlled trial.
  13. Clinico-epidemiological profile of acanthosis nigricans among children attending a Pediatric Dermatology Clinic
  14. Quantification of levels of biotin and copper in serum and hair samples of women with chronic telogen effluvium
  15. Hereditary Epidermolysis Bullosa–A clinical phenotype correlation with the Immunofluorescence mapping
  16. A retrospective analysis of dermoscopic features of cutaneous spindle shaped tumours.
  17. Efficacy of autologous platelet rich fibrin over moist sterile saline dressing in chronic trophic ulcers in Hansen’s disease patients-A randomized control trial.

Publications:

  1. 1. Behera B, Singh N, Chandrashekar L, Sathya AB, Thappa DM, Toi PC. Eosinophilic fasciitis associated with Raynaud's phenomenon, esophageal dysmotility, positive antinuclear antibody and anti-neutrophil cytoplasmic antibody. Indian J Dermatol Venereol Leprol. 2018;84(2):224-227.
  2. Behera B, Malathi M, Thappa DM, Vamanshankar H, Parida PK, Gochhait D. Xanthoma Disseminatum Presenting with Hoarseness. Iran J Otorhinolaryngol. 2017Nov;29(95):365-368.
  3. Behera B, Thomas E, Kumari R, Thappa DM, Jinkala S. Polymorphous presentation of subcutaneous phaeohyphomycosis: a rare occurrence. Int J Dermatol. 2018 Feb;57(2):e1-e3.
  4. Thappa DM, Malathi M. Topical therapy of psoriasis: Where do we stand? J Postgrad Med. 2017 Oct-Dec;63(4):210-212.
  5. Haridasan S, Parameswaran S, Bheemanathi SH, Chandrasekhar L, Suseela BB, Singh R, Rabindranath J, Padhi RK, Sampath E, Dubey AK, Puthenpurackal PSP. Subcutaneous phaeohyphomycosis in kidney transplant recipients: A series of seven cases. Transpl Infect Dis. 2017 Dec;19(6). doi: 10.1111/tid.12788. Epub 2017 Nov 27.
  6. Behera B, Gochhait D, Remya R, Resmi MR, Kumari R, Thappa DM. Follicular psoriasis - dermoscopic features at a glance. Indian J Dermatol Venereol Leprol. 2017 Nov-Dec;83(6):702-704.
  7. Gupta D, Kumari R, Thappa DM. Dermatitis Factitia. Indian Dermatol Online J. 2017 Sep-Oct;8(5):367.
  8. Behera B, Gochhait D, Thappa DM. Pseudoainhum and autoamputation associated with lamellar ichthyosis. Indian J Dermatol Venereol Leprol. 2017 Nov-Dec;83(6):728-729.
  9. Behera B, Chandrashekar L, Singh N, Thappa DM, Gochhait D. Lamellar ichthyosis associated bilateral pseudoainhum of fingers and toes successfully treated with tazarotene. Dermatol Ther. 2017 Sep;30(5).
  10. Behera B, Prabhakaran N, Naveed S, Kumari R, Thappa DM, Gochhait D. Dermoscopy of acrokeratosis verruciformis of Hopf. J Am Acad Dermatol. 2017 Aug;77(2):e33-e35.
  11. Behera B, Chandrashekar L, Gochhait D, Gupta D, Thappa DM. Crown vessels and follicular white dot: New dermoscopic findings in a case of solitary reticulohistiocytoma. J Am Acad Dermatol. 2018 Mar;78(3):e57-e59.
  12. Williams A, Chandrashekar L, Srivastava VM, Thomas M, Horo S, George R. Incontinentia pigmenti, an x-linked dominant disorder, in a 2-year-old boy with Klinefelter syndrome. Indian J Pathol Microbiol. 2017 Jul-Sep;60(3):424-426.
  13. Sudhesan A, Rajappa M, Chandrashekar L, Ananthanarayanan PH, Thappa DM, Satheesh S, Chandrasekaran A. Vascular endothelial growth factor (VEGF) gene polymorphisms (rs699947, rs833061, and rs2010963) and psoriatic risk in South Indian Tamils. Hum Immunol. 2017 Oct;78(10):657-663.
  14. Behera B, Remya R, Chandrashekar L, Thappa DM, Gochhait D, Dey B. Wickham's striae-like appearance in a case of nodular Kaposi's sarcoma: A dermoscopic pitfall. Indian J Dermatol Venereol Leprol. 2017 Sep-Oct;83(5):604-606.
  15. Behera B, Mathews I, Vinupriya S, Chandrashekar L, Thappa DM, Srinivas BH. Milia: A dermoscopic pitfall. J Am Acad Dermatol. 2017 Aug;77(2):e29-e31.
  16. Indhumathi S, Rajappa M, Chandrashekar L, Ananthanarayanan PH, Thappa DM, Negi VS. Pharmacogenetic markers to predict the clinical response to methotrexate in south Indian Tamil patients with psoriasis. Eur J Clin Pharmacol. 2017 Aug;73(8):965-971.
  17. Verma SB, Vasani RJ, Chandrashekar L, Thomas M. Seborrheic melanosis: An entity worthy of mention in dermatological literature. Indian J Dermatol Venereol Leprol. 2017 May-Jun;83(3):285-289.
  18. Revathy G, Usha R, Chandrashekar L, Singh N, Natarajan N, Thappa DM, Rajappa M. Effect of systemic methotrexate on lipid pentad index in psoriasis and its association with disease severity. Clin Chim Acta. 2017 Jun;469:10-12.
  19. Lakshmi MJD, Jaisankar TJ, Rajappa M, Thappa DM, Chandrashekar L, Divyapriya D, Munisamy M, Revathy G. Correlation of antimuscarinic acetylcholine receptor antibody titers and antidesmoglein antibody titers with the severity of disease in patients with pemphigus. J Am Acad Dermatol. 2017 May;76(5):895-902.
  20. Behera B, Chandrashekar L, Thappa DM, Srinivas BH, Pasayat PP, Laroiya I. Postsurgical pyoderma gangrenosum successfully treated with cyclosporine. Indian J Dermatol Venereol Leprol. 2017 May-Jun;83(3):412.
  21. Kamat D, Malathi M, Prabhakaran N, Thappa DM. Pseudoverrucous Papules and Nodules in an Infant with Penoscrotal Hypospadiasis. Indian Dermatol Online J. 2017 Nov-Dec;8(6):503-505.
  22. Mohan P, Munisamy M. Dysphagia Due to Kindler Syndrome. Am J Gastroenterol. 2017 Jul;112(7):983.
  23. Behera B, Gochhait D, Sridivya P, Chandana S, Thappa DM, Malathi M. Dermoscopy of a solitary verrucous plaque on the back. J Am Acad Dermatol. 2017 Aug;77(2):e37-e39.
  24. Behera B, Kumari R, Gochhait D, Thappa DM. Generalized lichen planus developing at the healed sites of erythema multiforme in a human immunodeficiencyvirus-seropositive patient. Indian J Dermatol Venereol Leprol. 2017 Jul-Aug;83(4):485-489.
  25. Nagarajan P, Thappa DM. Effect of an Educational and Psychological Intervention on Knowledge and Quality of Life among Patients with Psoriasis. Indian Dermatol Online J. 2018 Jan-Feb;9(1):27-32.
  26. Rajamohanan RR, Behera B, Jinkala S, Thappa DM. Solitary Dome-shaped Nodule over the Left Cheek. Indian J Dermatol. 2017 Sep-Oct;62(5):545-547.
  27. Bs B, Chittoria RK, Thappa DM, Mohapatra DP, Mt F, S D, Pandey S. Are lasers superior to lights in the photoepilation of Fitzpatrick V and VI skin types? - A comparison between Nd:YAG laser and intense pulsed light. J Cosmet Laser Ther. 2017 Oct;19(5):252-255.
  28. Thappa DM, Munisamy M. Research on psoriasis in India: Where do we stand? Indian J Med Res. 2017 Aug;146(2):147-149.

Extramural grants obtained:

  1. Evaluation of high frequency ultrasound and biomarkers for the diagnosis and management of type 1 lepra reaction – ICMR - Rs. 28,70,000 - completed
  2. Association of Tumour Necrosis Factor-α (TNF-α) promoter polymorphism with treatment outcome of non-segmental vitiligo in South Indian patients - IADVL hair and skin research grant- Rs. 2,50,000 - completed
  3. Aquaporin-3 levels in patients with vitiligo - IADVL hair and skin research grant- Rs. 2,50,000 - Rs. 2,50,000 – completed
  4. Characterization of various markers of nitroso-oxidative and cellular stress and their response to oral minipulse in non-segmental vitiligo; 1 year (2012-13); IADVL Pigment Research Grant- Rs.2,25,000 – completed
  5. Periorbital pigmentation and insulin resistance: Are they related? - IADVL hair and skin research grant- 2,95,000 - completed
  6. Factors affecting the severity of seborroheic dermatitis - IADVL hair and skin research grant- 1,82,000 - completed
  7. An active-control, Randomized, Prospective, Multicenter,Phase-III comparative clinical study to investigate, efficacy, safety and tolerability of Linezolid 1200mg SR tablet OD when compared with Linezolid 600mg tablet BD in subjects suffering with uncomplicated skin and soft tissue infections – Sponsored trial, Nexus CRO, Mumbai- Rs.1,80,000/- completed
  8. Quantification of levels of biotin and copper in serum and hair samples of women with chronic telogen effluvium -IADVL hair and skin research grant - Rs. 3,20,250/- completed
  9. Primer to gene based personalized management model to predict the efficacy of methotrexate monotherapy in patients with psoriasis in South Indian Population – DHR - 30,00,000/- ongoing
  10. Cognitive Behavioral Therapy versus Steroids for optimizing the conventional therapy of chronic spontaneous urticaria: a single blinded, factorial randomized controlled trial - CoBeTS trial -DST-SERB - Rs. 49,97,960/- approved