Research

Completed projects

Effect of nebivolol on endothelial dysfunction in coronary artery disease patients (NEDCAD)

Effect of ranolazine on glycemic status in patients with chronic angina patients with diabetes – a randomised parallel arm trial (CORANT)

A Comparative study of clinical efficacy of topical ketorolac vs bromfenac in reducing aqueous prostaglandins E2 levels and macular edema after cataract surgery

Efficacy of nitric oxide in stroke (ENOS)

Ongoing Projects

Efficacy and tolerability of modafinil in obstructive sleep apnea- pilot study

Effect of vitamin D on vascular health in hypertensive patients with vitamin D deficiency

Population pharmacokinetics and pharmacogenetics of tacrolimus in renal transplant patients

Population pharmacokinetics and pharmacogenetics of digoxin in cardiovascular disorder patients

Publications: List of last 2 year publications

Vishnukumar S, Umamaheswaran G, Anichavezhi D, Indumathy S, Adithan C, Srinivasan K, et al. P-glycoprotein expression as a predictor of response to neoadjuvant chemotherapy in breast cancer. Indian J. Cancer 2013;50(3):195–9.

Umamaheswaran G, Dkhar SA, Kalaivani S, Anjana R, Revathy M, Jaharamma M, et al. Haplotype structures and functional polymorphic variants of the drug target enzyme aromatase (CYP19A1) in South Indian population. Med. Oncol. Northwood Lond. Engl. 2013;30(3):665.

Subraja K, Dkhar SA, Priyadharsini R, Ravindra BK, Shewade DG, Satheesh S, et al. Genetic polymorphisms of CYP2C19 influences the response to clopidogrel in ischemic heart disease patients in the South Indian Tamilian population. Eur. J. Clin. Pharmacol. 2013;69(3):415–22.

Kumar SG, Adithan C, Harish BN, Sujatha S, Roy G, Malini A. Antimicrobial resistance in India: A review. J. Nat. Sci. Biol. Med. 2013;4(2):286–91.

Kumar DK, Shewade DG, Surendiran A, Adithan C. Genetic variation and haplotype structure of the gene Vitamin K epoxide reductase complex, subunit 1 in the Tamilian population. J. Pharmacol. Pharmacother. 2013;4(1):53–8.

Krishna Kumar D, Shewade DG, Loriot M-A, Beaune P, Balachander J, Sai Chandran BV, et al. Effect of CYP2C9, VKORC1, CYP4F2 and GGCX genetic variants on warfarin maintenance dose and explicating a new pharmacogenetic algorithm in South Indian population. Eur. J. Clin. Pharmacol. 2013;

Krishna Kumar D, Madhan S, Balachander J, Sai Chandran BV, Thamijarassy B, Adithan C. Effect of CYP2C9 and VKORC1 genetic polymorphisms on mean daily maintenance dose of acenocoumarol in South Indian patients. Thromb. Res. 2013;131(4):363–7.

Krishna Kumar D, Gopal Shewade D, Parasuraman S, Rajan S, Balachander J, Sai Chandran BV, et al. Estimation of plasma levels of warfarin and 7-hydroxy warfarin by high performance liquid chromatography in patients receiving warfarin therapy. J. Young Pharm. JYP 2013;5(1):13–7.

Arun Kumar AS, Umamaheswaran G, Padmapriya R, Balachandar J, Adithan C. Endothelial nitric oxide synthase gene polymorphisms and the risk of acute myocardial infarction in a South Indian population. Mol. Biol. Rep. 2013;40(2):1275–81.

Selvarajan S, George M, Kumar SS, Dkhar SA. Clinical trials in India: Where do we stand globally? Perspect. Clin. Res. 2013;4(3):160–4.

Selvarajan S, Dkhar SA, Pillai AA. Good! Is it the best??? J. Pharmacol. Pharmacother. 2013;4(3):220–1.

Sandhiya S, Melvin G, Kumar SS, Dkhar SA. The dawn of hedgehog inhibitors: Vismodegib. J. Pharmacol. Pharmacother. 2013;4(1):4–7.

Rajani AK, Ravindra BK, Dkhar SA. Telaprevir: changing the standard of care of chronic hepatitis C. J. Postgrad. Med. 2013;59(1):42–7.

George M, Selvarajan S, S S-K, Dkhar SA, Chandrasekaran A. Globalization of clinical trials - where are we heading? Curr. Clin. Pharmacol. 2013;8(2):115–23.

George M, Amrutheshwar R, Rajkumar RP, Kattimani S, Dkhar SA. Newer antipsychotics and upcoming molecules for schizophrenia. Eur. J. Clin. Pharmacol. 2013;69(8):1497–509.

Umamaheswaran G, Krishna Kumar D, Kayathiri D, Rajan S, Shewade DG, Dkhar SA, et al. Inter and intra-ethnic differences in the distribution of the molecular variants of TPMT, UGT1A1 and MDR1 genes in the South Indian population. Mol. Biol. Rep. 2012;39(5):6343–51.

Surendiran A, Kaku MV, Adithan C. Medication error - Inadvertent high dose intradermal cloxacillin induced skin necrosis. Indian J. Pharmacol. 2012;44(1):122–3.

Krishnakumar D, Gurusamy U, Dhandapani K, Surendiran A, Baghel R, Kukreti R, et al. Genetic polymorphisms of drug-metabolizing phase I enzymes CYP2E1, CYP2A6 and CYP3A5 in South Indian population. Fundam. Clin. Pharmacol. 2012;26(2):295–306.

George M, Shewade DG, Kumar SV, Adithan C. Effect of anti-tuberculosis therapy on polymorphic drug metabolizing enzyme CYP2C9 using phenytoin as a probe drug. Indian J. Pharmacol. 2012;44(4):485–8.

Damodaran SE, Pradhan SC, Umamaheswaran G, Kadambari D, Reddy KS, Adithan C. Genetic polymorphisms of CYP2D6 increase the risk for recurrence of breast cancer in patients receiving tamoxifen as an adjuvant therapy. Cancer Chemother. Pharmacol. 2012;70(1):75–81.

Anichavezhi D, Chakradhara Rao US, Shewade DG, Krishnamoorthy R, Adithan C. Distribution of CYP2C19*17 allele and genotypes in an Indian population. J. Clin. Pharm. Ther. 2012;37(3):313–8.